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Psychedelic drug Wikipedia As Ray pointed out, different molecules may also have significant affinity for other types of brain receptors. Wood et al. compared the effect of DOI with amphetamine and MK-801 on PFC neuronal activity in freely moving rats. They implanted microelectrode arrays in male rats and measured neuronal activity in the OFC and ACC. Their study was the first to investigate the effects of a psychedelic on cortical neurophysiology in awake animals. They analyzed neuronal population activity, LFP power, and correlations between spike-discharge power and LFP power. DOI (1 mg/kg) significantly reduced population activity in OFC compared with baseline, with larger doses of DOI producing greater population suppression. Using in vivo studies in pigs, they determined that the 5-methoxy of the trisubstituted phenyl ring is rapidly O-demethylated. After intravenous administration of 25B-NBOMe [N-(2-methoxybenzyl)-2,5-dimethoxy-4-bromophenethylamine (Cimbi-36)] to a pig, anal